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simeon weight loss plan : I just noticed that Methamphetamine redirects to the Amphetamines article; shouldn't they have separate pages? Or is the inherent ambiguity among street amphetamines the reason for this redirect? Personally, I think that "Amphetamines" should redirect to the Amphetamines category so it will function as a kind of list known amphetamines, whereas "Amphetamine", "Dexedrine", and "Adderall" should all probably redirect to a separate page with sections for each. BTW if you do want a separate page for methamphetamine here's one I slapped together real quick:


==The Basics==

===Introduction and Basic Description===
Methamphetamine is a stimulant drug of the amphetamine class.

===Timeline of Experience===
Onset: 0-1 hour, Peak: T+2.00, Plateau: T+4, Afterglow: T+8, End of experience: T+10.

===Effects===
Methamphetamine's effects are similar to other amphetamines including euphoria, increased heart rate, increased energy, increased alertness, irritability, sociability.

===Dosages===
Dosage varies greatly depending on purity and tolerance, but some report anywhere from 5-150mg.

===Method of administration===
Smoking, Oral ingestion, Insufflation, IV injection.

===Slang===
Meth, Ice, Crank, Glass, Tweak, Crystal, Desoxyn

===Contraindications and Overdose===
Like most amphetamines, methamphetamine is a stimulant and one should be careful when combining with other uppers or downers. Another potential harm to avoid is serotonin syndrome, be careful not to mix meth with SSRI's or other drugs with serotonergic properties.

===Negative Short-Term Side Effects===
Desire to redose.

===Negative Long-Term Side Effects===
Dopamine Neurotoxicity

===Addiction and Withdrawal Issues===
Tolerance builds quickly and addiction is common and its effects can be devastating, stay safe!

===Harm Reduction===
Avoid the urge to redose, and be very careful to stay safe!

===Legal Issues===

==Background and Chemistry==

===History of Drug===

===Chemistry===
Quite similar to [[Amphetamine]] with the addition of a methyl group to the terminal amine.

===Pharmacology===
Methamphetamine's effects are similar to other amphetamines including general CNS stimulation.

===Preparation===

===Mechanism of Action===
Methamphetamine, like other many other [[amphetamines]], is a mixed Dopamine, Norepinephrine, and Serotonin releasing agent and reverses the transporters for these monoamines.

==Trip reports and links==

===Trip Reports===
Probably a paragraph giving links to cool TRs here and on other sites. Don't re-write or copy/paste the whole trip report.

===Links===

* [http://en.wikipedia.org/wiki/Methamphetamine Wikipedia Methamphetamine page]
* [http://www.erowid.org/chemicals/meth/ Erowid Methamphetamine Vault]

[[Category:Drug FAQs]] [[Category:Amphetamines]]

simeon weight loss protocol : Owing to quite a bit of knowledge about virtually all facets of methamphetamine as it is differentiated from other amphetamines, I whole-heartedly agree with this and will begin my own Methamphetamine FAQ for inclusion in the BL Wiki. The two are separable enough that METH warrants its own FAQ in my opinion.

EDIT: Being that I'm about to undertake a great deal of work on behalf of this proposed separable Wiki entry on Methamphetamine, it'd be awesome if a moderator/administrator would let me know not to bother if they think it unnecessary

simeon's diet list : I can't speak for the mods per se, but no one is going to complain if you start writing up a detailed FAQ! And, especially at our current pace, all contributions are appreciated and essential to getting the ball rolling. Oh and if you aren't familiar with wiki formatting, please don't let that hinder you. Just post it here and we can collectively give it touch ups if needed. My hope is that even after the Methamphetamine FAQ page is created on the wiki that this thread can still be used for suggesting future edits!

simeon's weight loss : Originally Posted by Enix150 I can't speak for the mods per se, but no one is going to complain if you start writing up a detailed FAQ! And, especially at our current pace, all contributions are appreciated and essential to getting the ball rolling. Oh and if you aren't familiar with wiki formatting, please don't let that hinder you. Just post it here and we can collectively give it touch ups if needed. My hope is that even after the Methamphetamine FAQ page is created on the wiki that this thread can still be used for suggesting future edits! It's... ~65% completed. I'm starting training for a new job this week so I've turned over some of the sections to Amu for some assistance. It'll be up shortly, I'll post it here with citations as well!

~ vaya

simeon's weight loss cure : Here's a question for you. I've always been curious about crank and where people get it - in general, not looking to source. Is it typical for dealers of crack and heroin to traffic in crank as well? I've been asking around, in several cities, but none of my dealers know anything about it. All of my dealers are black though, and from what I've seen on the ol' TV, that's not the stereotypical dealer.

Or, is the other TV stereotype possibly true - that it's sold at rest stops and other trucker hang outs? Haven't seen it there, at least that I'm aware of. Maybe I don't know what kind of a dude this would look like.

Are both of these stereotypes wrong? Again, not sourcing, but there isn't enough info on bluelight for me to be able to get an idea for what the generals are on this.

simeon's weight loss protocol : Originally Posted by Fireandrain Here's a question for you. I've always been curious about crank and where people get it - in general, not looking to source. Is it typical for dealers of crack and heroin to traffic in crank as well? I've been asking around, in several cities, but none of my dealers know anything about it. All of my dealers are black though, and from what I've seen on the ol' TV, that's not the stereotypical dealer.

Or, is the other TV stereotype possibly true - that it's sold at rest stops and other trucker hang outs? Haven't seen it there, at least that I'm aware of. Maybe I don't know what kind of a dude this would look like.

Are both of these stereotypes wrong? Again, not sourcing, but there isn't enough info on bluelight for me to be able to get an idea for what the generals are on this. Stereotypes generally bear some merit, but as with all illicit drug waves, methamphetamine comes from a near-infinite array of diverse people from all locations and discussing whether or not the stereotypes are factual or not seems kind of pedantic, not to mention irrelevant.

You're right, this isn't necessarily sourcing, but it's too close to it for comfort and I'd rather we stop this conversation before it begins. After all, were it theoretically a legitimate topic of discussion, it doesn't even belong in this thread. I wouldn't back it being connected with the Methamphetamine Wiki project because we will not be discussing stereotyped sources of the illicit drug within the confines of the Wiki page. That information does not fall within the realm of curiosity and harm reduction.

Take care!

~ vaya

simeones diet : This is based off of Enix150's outline of backbone topics. It is open to scrutiny and suggestions. this is not the completed version! I am halfway completed some of the more advanced topics. Please post any contributions in this thread, or PM me directly!


==The Basics==

===Introduction and Basic Description===

Methamphetamine, also known as desoxyephedrine, N,a-dimethylphenethylamine and N,a-dimethylbenzeneethanamine,(2) is a highly-potent central nervous system (CNS) stimulants. Methamphetamine is a member of the amphetamine group of sympathomimetic amines. (1)

Methamphetamine is one of the most commonly abused drugs worldwide, second only to Cannabis, with an estimated prevalence of 0.4 percent of the world’s population consuming it (8, 20). It is used recreationally to induce feelings of increased sociability, euphoria, vigilance, energy/reduction of fatigue and increased confidence. Methamphetamine is also recognized for its ability to heighten sexual pleasure and increase sexual stamina (6).

In medical communities of many countries, methamphetamine hydrochloride (marketed under the trade name Desoxyn) is indicated as a pharmacotherapeutic treatment for Attention-Deficit Hyperactivity Disorder (ADHD) and as an anorectic for the short-term treatment of exogenous obesity. Methamphetamine may also be prescribed as an “off-label” treatment for narcolepsy (4). Desoxyn preparations are presently restricted to immediate-release tablets containing 5mg of the dextratory isomer of methamphetamine hydrochloride (5).

===Timeline of Experience===

The timeline of the methamphetamine experience is heavily influenced by dosage and route-of-administration. Below are approximated timeline values for methamphetamine with regard to varying types of drug administration for non-tolerant users(13):

====Oral====
Coming Up: 20-70 minutes (dependant on form and stomach contents)
Duration: 3-5 hours
Coming Down: 2-6 hours
Residual: Up to 24 hours

====Insufflated====
Onset: 5-10 minutes
Duration: 2-4 hours
Coming Down: 2-6 hours
Residual: Up to 24 hours

====Vaporized====
Onset: 0-2 minutes
Duration: 1-3 hours
Coming Down: 2-4 hours
Residual: Up to 24 hours

====Intravenous (IV)====
Onset: 0-2 Minutes
Duration: 4-8 hours
Coming Down: 2-4 hours
Residual: Up to 24 hours

I’d really like to make this less of a mere re-hash of Erowid’s page; if you’ve got a solid alternative source for the “Timeline of Experience” section please PM me right away! Thank you! ~ vaya

===Methamphetamine Effects===

*Methamphetamine produces a wide variety of physiological and behavioral/psychological effects in humans. It is important to be mindful of the fact that the incidence and prevalence of methamphetamine’s individual physiological, behavioral and psychological effects are dose-dependant and can differ significantly from one person to the next in a given population of users.

====Physiological====
Anorexia (Loss of appetite)Insomnia (Inability to sleep, disrupted sleep architecture)Mydriasis (dilated pupils)HeadacheDiaphoresis (excessive sweating)Tachycardia (dangerously rapid heart rate)Bradycardia (dangerously slow heart rate)Trismus (jaw-clenching)Bruxia (teeth-grinding)Agitation/RestlessnessIncreased energySexual arousalXerostomia (dry mouth)(9), (11), (12)

*At higher doses, or in individuals predisposed to cardiovascular conditions, the physiological effects of methamphetamine may become much more severe, and include(10):
PalpitationsArrhythmias (irregular heartbeat)ConvulsionsHeart attackStrokeDeath

====Behavioral & Psychological====
EuphoriaIncreased confidence/sociabilityIncreased reaction timeIncrease in compulsive behaviorsLowered inhibitionsIncrease in selective attentionIncrease in motivationImproved reflexesEmpathy, feelings of opennessAggressionIrritabilityAnxiety/PanicDepression

Long-term, continuous use of methamphetamine can result in a debilitating mental state known as “amphetamine psychosis” that closely mimics the symptoms of paranoid schizophrenia. The incidence of psychosis produced my chronic methamphetamine use is generally higher than that produced by amphetamine. Symptoms of amphetamine psychosis include megalomania (inflated ego, sense of power), paranoid delusions, sensory hallucinations (generally auditory and tactile, but can include visual and olfactory hallucinations), depersonalization, violence and homicidal/suicidal ideations (25).

===Dosages===

In order to avoid complications and minimize the incidence of negative side effects, it is important to emphasize that dosages for methamphetamine can vary due to many factors, not the least of which is accumulated tolerance to the drug from past exposure. The lowest dose possible should always be attempted first. The following dosages represent approximations for non-tolerant users classified according to route of administration under the assumption of pure methamphetamine (13):

====Oral Dosage====
Threshold: 5mg
Light stimulation: 5-15mg
Common: 10-30mg
Strong: 20-60mg
Very Strong (or with tolerance): 40-150mg

====Insufflated====
Threshold: 5mg
Light stimulation: 5-15mg
Common: 10-40mg
Strong: 30-60mg
Very Strong: 50+mg

====Vaporized====
Threshold: 5-10mg
Light stimulation: 10-20mg
Common: 10-40mg
Strong: 30-60mg
Very Strong: 50+mg

====Injected/IV====
Threshold: 5mg
Light stimulation: 5-10mg
Common: 10-40mg
Strong: 30-60mg
Very Strong: 50-100mg

I’d really like to make this less of a mere re-hash of Erowid’s page; if you’ve got a solid alternative source for the “Dosages” section please PM me right away! Thank you! ~ vaya

===Method of administration===

====Method 1====

====Method 2====

===Slang===
Methamphetamine has many common street names, sometimes causing confusion arising from geographic and procedural differences in clandestine production. Some common colloquial terms referring to methamphetamine are listed below:

CrankMethTinaGlassIceCrystalCrissyGo-FastShardsGoWhizzDopeSpeed“Biker Dope”FireGakGearTwackTweakChalk“Redneck [or Poor Man’s] Cocaine”(36)
Slang terminology contributed by littlepenguin

==Problems==

===Contraindications and Overdose===

Expand further here on dosage issues, also flag dangerous combos (DXM, MDMA) and combos which make the drug less effective (MDMA + prozac)

===Negative Short-Term Side Effects===
Increased blood pressureIncreased respirationHyperthermiaAnorexiaInsomniaParanoiaIrritabilityEmotional labilityRepetitive, obsessive-compulsive behaviorsMydriasis (dilated pupils)Diaphoresis (excessive sweating)NauseaTremorsDry mouthPoor oral hygieneHeadacheBruxism (jaw clenching)SeizuresSudden death (cardiac arrest)(35)
Short-term effects contributed by littlepenguin

===Negative Long-Term Side Effects===
Monoamine receptor downregulationCompromised functioning of monoamine transportersNeurotoxicity resulting from oxidative stressHigh blood pressurePersistent anxietyInsomniaPsychosis (including sensory hallucinations and paranoid delusions)Homicidal/Suicidal ideationCompromised immune systemCracked teethSores, skin infections and acne from poor hygiene and compulsive picking behaviorLiver damageIncrease in risk-taking behaviorInjury to the fetus if used prematurely; injuries include premature birth, infant cardiac defects and cleft palate, among othersMuscular degenerationLoss of bone densityImpairment of oral hygieneHeart palpitationsRespiratory irritationConstipationCrampingDehydrationDiarrheaMalnutritionAnorexia & weight lossHeadacheKidney infectionsBladder infectionsStrokeDeath(35)
Long-term effects contributed by littlepenguin

===Addiction and Withdrawal Issues===

Methamphetamine is widely considered the most powerful, and arguably the most reinforcing, of the stimulant drugs-of-abuse. Studies whose participants had sought treatment for methamphetamine addiction show relapse rates of as high as 92%, although more conservative estimates place the relapse rate of those who have undergone treatment at just above 60% at 12 months post-treatment (29).

Methamphetamine Withdrawal Syndrome

Suddenly stopping chronic methamphetamine use causes an array of withdrawal-related psychological and behavioral symptoms such as disrupted sleep architecture/insomnia, significant depression, anxiety and intense cravings for the drug. Another hallmark of methamphetamine withdrawal is impairment on a battery of cognitive functions; these include memory, divided and directed attention, motivation and planning. (26) Other common effects of withdrawal include “…hyperphagia [excessive eating], agitation, vivid and unpleasant dreams, [and] reduced energy…” (20)

The syndrome is formally classified by the American Psychiatric Association as “amphetamine-type stimulant withdrawal syndrome.” (27) Research currently suggests that the syndrome’s etiology results “…from the depletion of presynaptic monoamine stores, down-regulation of receptors and neurotoxicity. (20)” (28)

===Harm Reduction===

===Legal Issues===

====United States====
In the United States, methamphetamine is classified as a Schedule II substance - a substance with established medical and clinical applications and with a high liability for abuse. It is illegal to possess without a prescription or government-issued license. It is currently sold by Abbot Pharmaceuticals under the trade name Desoxyn, and generically by Mylan Pharmaceuticals as “methamphetamine HCl” in the form of 5mg instant-release tablets.

Sanctions against the possession of materials considered precursors in the manufacture of methamphetamine were instituted in 1983, and the United States government began to aggressively pursue the elimination of clandestine methamphetamine laboratories that had become driving forces behind the rapid spread and rising popularity of methamphetamine in America. Over time, progressively more restrictions were placed on over-the-counter cold and sinus remedies that included the ingredient pseudoephedrine, a critical component in the methamphetamine production process. The U.S. Combat Methamphetamine Act of 2005 imposed federally-regulated laws stating that pseudoephedrine-containing products were to be sold behind the counter of nationwide drug stores. The law made it a requirement that consumers presented photo ID and signed a register when purchasing these products, and that a limit be placed on the amount of product one could buy at a given time. As a sub-division of the USA Patriot Act, consumers' transactions at various stores could be electronically monitored in the hopes of identifying illegal diversion (16)

====Canada====
In 1996, Canada’s federal government passed the Controlled Drugs and Substances Act, establishing firmer guidelines for the regulation of licit and illicit substances within the country (31). In August of 2005, Canada moved methamphetamine into its most restrictive class of controlled substances, Schedule I, alongside cocaine and heroin. Canada currently does not recognize methamphetamine as a drug with medical value (32).

Placing methamphetamine apart from other amphetamines (Schedule III) imposes harsher legal consequences for those illicitly involved with the substance: Possession of methamphetamine carries a maximum penalty of $5,000 and/or up to three years in prison, and the maximum penalty for production/distribution of the drug rose from a maximum of 10 years in prison to life imprisonment in 2005 (30).

====Australia====
Unlike Canada, the Australian government recognizes methamphetamine as a substance with medical value. It is listed in Schedule 8 of the Australian Standard for the Uniform Scheduling of Drugs and Poisons. This indicates that methamphetamine is a federally controlled substance “…which should be available for use but require[s] restriction of manufacture, supply, distribution, possession and use to reduce abuse, misuse and physical or psychological dependence.” (33)

====United Kingdom====
On January 18th, 2007, the United Kingdom complied with a June 2006 recommendation made by the Advisory Council on the Misuse of Drugs to reclassify methamphetamine. Whilst previously classified in Class B (except in injectable ampoule or liquid vial forms) , methamphetamine became a Class A drug under the Misuse of Drugs Act of 1971, the UK’s most restrictive controlled drug class (34).

==Background and Chemistry==

===History of Methamphetamine===
The discovery of methamphetamine followed shortly after amphetamine was created in Germany in1897. Methamphetamine was first synthesized in Japan in 1919, but remained obscure and without practical use for some time afterwards. The first widespread use of methamphetamine was during World War II by soldiers in the German, American and Japanese militaries. The drug was dispensed to soldiers by heir commanding officers in order to increase bravery, aggression and resiliency when sleep and food were not abundant. It is rumored that Japanese fighter pilots utilized methamphetamine to help spur enthusiasm for kamikaze attacks, such as those enacted on Pearl Harbor. The very first human methamphetamine epidemic was a direct result of wartime manufacture of methamphetamine; following the final days of World War II, Japan discovered itself with an abundant supply of the drug and its high solubility in water made it an ideal stimulant for intravenous abuse. In 1951, the Japanese government responded by banning methamphetamine(16).

On December 31st, 1943, Ovation Pharmaceuticals received FDA approval to begin marketing d-methamphetamine hydrochloride in the United States (14). In the U.S., the 1950’s marked a cultural explosion of amphetamine (Dexedrine, Benzedrine) and methamphetamine (Desoxyn, Methedrine) misuse by college students, truck drivers, athletes and professionals. The 1960’s marked a substantial increase in IV methamphetamine abuse, and the United States government responded with the 1970 Controlled Substances Act that drastically reduced the production of injectable meth. Methamphetamine was formally classified as a Schedule II substance according to the Controlled Substances Act on July 7th, 1971 (3).

The abuse of methamphetamine experienced a resurgence in the late 1980's as illicit chemists discovered that the drug was easily made via the reduction of two legal stimulant compounds, ephedrine and pseudoephedrine, using legal and easily obtainable chemical precursors to accomplish the intermediary steps required for synthesis. Methamphetamine quickly became favored by truck drivers, western motorcycle gangs and the homosexual community and clandestine production within the United States has seen a tremendous increase since 1991.

Methamphetamine continues to be one of the most popular and widely used drugs of abuse, especially in North America, where its availability and distribution has spread from the west coast of the United States to its eastern coast (15). Regional anti-methamphetamine campaigns and sensationalist press coverage of the present methamphetamine “epidemic” have caused meth to become one of the most stigmatized substances in America’s War on Drugs.

In late April of 2010, Mylan Pharmaceuticals introduced the first generic form of Desoxyn, methamphetamine hydrochloride tablets USP, 5mg (7).

===Chemistry===

http://www.erowid.org/chemicals/show...etamine_3d.jpg (17)
Introduction to the Forensic Chemistry of Methamphetamine

===Pharmacology===

Methamphetamine is derived from amphetamine (a-methylphenethylamine) and is synonymous withN-methyl-1-phenylpropan-2-amine, the N-methyl derivative of amphetamine. Methamphetamine is also known as methylamphetamine, metamfetamine, methyl-beta-phenylisopropylamine, 1-phenyl-2-methylaminopropane and N,a-Dimethylbenzeneethanamine (2, 18 ).

Owing largely to its structural similarity with monoamine neurotransmitters, including dopamine and norepinephrine, methamphetamine substitutes for these monoamines at their respective transporters. These predominately include the dopamine transporter (DAT), the norepinephrine transporter (NET), and the serotonin transporter (SERT). Methamphetamine also exerts its action by reversing the action of the vesicular monoamine tranporter-2 (VMAT-2), and thus expelling dopamine (DA), serotonin (SER) and norepinephrine (NE) into the cytosol between neurons. Methamphetamine's action on VMAT-2 alters the neuronal roles of DAT, NET and SERT with the result that these monoamines are transported from the cytosol into nerve synapses and increasing levels of these neurotransmitters in many parts of the brain (21). The brain areas affected most predominately by methamphetamine-induced neurotransmitter release are the pre-frontal cortex (PFC), striatum and areas of the mesolimbic system such as the ventral tegmental area (VTA) and substantia nigra. The activity of DA, the neurotransmitter most heavily affected by methamphetamine, is increased most significantly in the "...mesolimbic, mesocortical circuit and nigrostantial pathways." (19). Additionally, "in vitro studies indicate that methamphetamine is twice as potent at releasing noradrenaline as dopamine, and its effect is 60-fold greater on noradrenaline than serotonin release." (20)

===Pharmacokinetics===

Methamphetamine undergoes hepatic metabolism via several mechanisms. When catalysed by cytochrome P450 2D6, methamphetamine undergoes N-demethylation (producing amphetamine) and aromatic hydroxylation (producing 4-hydroxymethamphetamine). Beta-hydroxylation produces norephedrine. The various metabolites resulting from the metabolism of methamphetamine do not significantly contribute to its effects on the human body (22, 23).

70% of a dose of methamphetamine is excreted in urine within 24 hours (24). “The terminal plasma half-life of methamphetamine of approximately 10 hours is similar across administration routes, but with substantial inter-individual variability. Acute effects persist for up to 8 hours following a single moderate dose of 30 mg… via vapour inhalation (smoking), methamphetamine bioavailability ranges from 67% to 90%... [and] is 79% bioavailable via the intranasal route.” (20)

===Preparation===

Methamphetamine is prepared via the reduction of ephedrine or pseudoephedrine into desoxyephedrine. For educational purposes, that is all you need to know.

===Mechanism of Action===

==Trip Reports & Links==

===Trip Reports===

===Links===
This is a very rough key to the (x) numbers peppering the document. If it says “Meth was first manufactured in 1919…. (14)” it means the link below numbered 14 is the corresponding link. This is preliminary, and for the moment, merely a place to make public where I’ve thus far found my information. Obviously citations need to be formatted and inserted correctly, blah blah blah. More to come – much more. ~ vaya

(1) Glen R. Hanson, Peter J. Venturelli, Annette E. Fleckenstein (2005-11-03). "Drugs and society (Ninth Edition)". Jones and Bartlett Publishers. ISBN 9780763737320. Retrieved 2011-04-19.

(2)http://www.chemspider.com/Chemical-Structure.10379.html (retrieved 14 Jan 2012)

(3) http://isomerdesign.com/Cdsa/schedul...=U&structure=C

(4) http://mental-health.emedtv.com/meth...ed-for-p2.html

(5) http://www.fda.gov/downloads/Drugs/D.../ucm088582.pdf

(6) http://www.emcdda.europa.eu/publicat...ethamphetamine

(7) http://investor.mylan.com/releasedet...leaseID=463277

(8) http://www.unodc.org/unodc/en/frontp...the-world.html

(9) Mohler; Townsend (2006-04-01). Advanced Therapy In Hypertension And Vascular Disease. PMPH-USA. p. 469. ISBN 978-1550093186.

(10) "Physiological Effects of a Methamphetamine Overdose | Montana State University". Montana.edu. Retrieved 2011-01-09.

(11) "Methamphetamine | Center for Substance Abuse Research (CESAR)". Cesar.umd.edu. Retrieved 2011-01-09.

(12) "Erowid Methamphetamines Vault: Effects". Erowid.org. Retrieved 2011-01-09.

(13) http://www.erowid.org/chemicals/meth/meth_dose.shtml

(14) http://www.prescriptiondrug-info.com/Drugs/Desoxyn/

(15) http://www.montgomerycountytn.org/Co...thHistory.aspx

(16) http://www.albuquerquebreakingbad.com/history-of-meth

(17) http://www.erowid.org/chemicals/meth...etamine_3d.jpg

(18 ) http://amphetamines.com/methamphetamine-faq/index.html

(19) Wise R. A. Dopamine, learning and motivation. Nat Rev Neurosci 2004; 5: 483–94.

(20) https://secure.muhealth.org/~ed/stud..._104_p1085.pdf

(21) http://www.rnceus.com/meth/methpharm.html

(22) Kraemer T., Maurer H. H. Toxicokinetics of amphet-
amines: metabolism and toxicokinetic data of designer drugs, amphetamine, methamphetamine, and their N-alkyl derivatives. Ther Drug Monit 2002; 24: 277–89.

(23) Lin L. Y., Di Stefano E. W., Schmitz D. A., Hsu L., Ellis S. W., Lennard M. S. et al. Oxidation of methamphetamine and methylenedioxymethamphetamine by CYP2D6. Drug Metab Dispos 1997; 25: 1059–64.

(24) Kim I., Oyler J. M., Moolchan E. T., Cone E. J., Huestis M. A. Urinary pharmacokinetics of methamphetamine and its metabolite, amphetamine following controlled oral admin- istration to humans. Ther Drug Monit 2004; 26: 664– 72.

(25) Angrist B. M., Gershon S. The phenomenology of experi- mentally induced amphetamine psychosis—preliminary observations. Biol Psychiatry 1970; 2: 95–107.

(26) Kalechstein A. D., Newton T. F., Green M. Methamphet- amine dependence is associated with neurocognitive impairment in the initial phases of abstinence. J Neuropsy- chiatry Clin Neurosci 2003; 15: 215–20.

(27) American Psychiatric Association. Diagnostic and Statisti- cal Manual of Mental Disorders, 4th edn. Text revision edn. Washington DC: American Psychiatric Association; 2000.

(28) Meredith C. W., Jaffe C., Ang-Lee K., Saxon A. J. Implica- tions of chronic methamphetamine use: a literature review. Harv Rev Psychiatry 2005; 13: 141–54.

(29) http://www.ncsacw.samhsa.gov/files/M...d%20Safety.pdf

(30) http://www.ctv.ca/CTVNews/TopStories...l_meth_050811/

(31) http://isomerdesign.com/Cdsa/

(32) http://en.wikipedia.org/wiki/Legal_s...etamine#Canada

(33) Australian Government. Department of Health and Aging. Therapeutic Goods Administration (June 2008) (PDF). Standard for the uniform scheduling of drugs and poisons no. 23. Canberra: Commonwealth of Australia. ISBN 1741865964. Retrieved 2009-04-06.

(34) http://news.bbc.co.uk/2/hi/uk_news/politics/5079266.stm

(35) http://www.cesar.umd.edu/cesar/drugs/meth.asp

(36) www.tweaker.org

simeons a new approach to obesity : 1/29/12 10:10 P.M. EST
Wiki article edited above to include 14 more references and tentatively completed sections on Pharmacology, Pharmacokinetics, Addiction & Withdrawal, Legal Status in the US, Australia, Canada and the UK, and several other minor/moderate updates/revisions.

Any help with this one would be great (i.e. Trip Reports, Methods of Administration, Contraindications/Overdose, Slang, etc.). I have to admit I'm a *little* worn out after writing out what I have so far. Also, critiques and additions WELCOME, by anyone - And that includes you!

Much love,
~ vaya

simeons diet : in the late 70s, early-mid 80s, I was getting decent cat piss smelling CRANK from biker gangs I befriended.
<snip> i did the OLD crank from 77 - solidly for 8 years. and Vaya, how can someone be so knowledable about crank and you havent done it, ever? thats like a counselor by the book.yes?

simeons diet bad : under ROA, you should add Plugging, ie: Booty Bump
maybe this would be considered to be under the category of 'injection,' but you don't use a needle, but a small syringe w/o a needle, or some just put a little on their finger and thump it right up the shoot.

any q's about this, let me know

also under ROA, you have a method listed as "smoked." Technically, this is incorrect. Vaporized would be the correct term, wouldn't it?

simeons diet cost : Originally Posted by somestuff101 in the late 70s, early-mid 80s, I was getting decent cat piss smelling CRANK from biker gangs I befriended.
[.....] i did the OLD crank from 77 - solidly for 8 years. and Vaya, how can someone be so knowledable about crank and you havent done it, ever? thats like a counselor by the book.yes? Who says I've never done Meth? lol I used to dabble, and now I'm prescribed it. But I'm sober from illicit drugs now, my motivation lies within a fiery intrinsic interest in this website's subject matter.

I see you're new to Bluelight; Welcome!! You may have noticed that I edited your post slightly. Even if you hadn't meant your remarks as racist, someone else may have found them as such. Aside from that, we want to keep our eyes on the horizon in the name of this Wiki project, not on whether or not a particular ethnic group may or may not be the current predominant suppliers of a drug in a given country. Don't take offense, simply keep those kinds of comments to yourself in the future. Cool?

And... Since you used METH for eight years, perhaps you have something you'd be willing to contribute to our Methamphetamine Wiki here? It would be greatly appreciated, and credit is given where credit is due

~ vaya

simeons diet foods : Originally Posted by littlepenguin under ROA, you should add Plugging, ie: Booty Bump
maybe this would be considered to be under the category of 'injection,' but you don't use a needle, but a small syringe w/o a needle, or some just put a little on their finger and thump it right up the shoot.

any q's about this, let me know

also under ROA, you have a method listed as "smoked." Technically, this is incorrect. Vaporized would be the correct term, wouldn't it? You're correct, vaporized would be the correct terminology rather than "smoked" because methamphetamine doesn't (or, at least, shouldn't) combust! Thanks for pointing that out.
And, yes, if someone else doesn't write up the section on ROA, I'll do it - it simply may take time. What I've got down so far represents about two weeks of rather extensive research - especially since sound citations are critical to the credibility of the FAQ. Plugging will definitely be on there; my favorite ROA for amphetamines by far. Thanks for the suggestions, littlepenguin. They go a long way.

~ vaya

simeons diet results : slang: crank, meth, tina, glass, ice, crystal, crissy, go-fast, shards, go, whizz, dope, shit, speed, biker dope, fire, gak, gear, twack, tweek, chalk, redneck cocaine

negative short term effects:
Increased blood pressure and breathing rate
Dangerously elevated body temperature
Loss of appetite
Sleeplessness
Paranoia, irritability
Unpredictable behavior
Performing repetitive, meaningless tasks
Dilated pupils
Heavy sweating
Nausea, vomiting, diarrhea
Tremors
Dry mouth, bad breath
Headache
Uncontrollable jaw clenching
Seizures, sudden death

negative long term effects:
Damaged nerve terminals in the brain
Brain damage similar to Parkinson's or Alzheimer's Diseases
High blood pressure
Prolonged anxiety, paranoia, insomnia
Psychotic behavior, violence, auditory hallucinations and delusions
Homicidal or suicidal thoughts
Weakened immune system
Cracked teeth
Sores, skin infections, acne
heart infections
lung disease
liver damage
Increased risk behavior, especially if drug is injected
When used by a pregnant woman, premature birth; babies suffer cardiac defects, cleft palate, and other birth defects
Death
tooth decay
muscle loss
bone loss
gum problems
tooth loss
heart palpitations
stroke
reduction in volume of oxygen your lungs can hold (vaporizing/smoking)
constipation
cramping
dehydration
diarreha
malnutrition
anorexia
weight loss
headache
kidney infections
kidney stones
bladder infections
difficulty urinating


supplements: (harm reduction/tolerance reduction)
Calcium supplement 1000mg
Melatonin 5mg
L-tryptophan 400-500mg (free form of amino acid)
L-Tyrosine 400-500mg (free form of amino acid)
complete amino acid nutrition supplement (found in GNC-like stores)
Multivitamins
Vitamin C

simeons diet texas : sources: http://www. cesar.umd. edu/cesar/drugs/meth.asp
www. tweaker. org

simeons hcg diet : Originally Posted by littlepenguin sources: http://www. cesar.umd. edu/cesar/drugs/meth.asp
www. tweaker. org Thank you so, so very much littlepenguin! Our first contributor!
I've just posted a revamped version of the Wiki to include the information you provided. Please do not take offense if I re-worded, re-organized or added technical terms (ex. "Bruxism (jaw clenching)." You were responsible for those frameworks and you came through!
Thank you for the citations as well. You've been given credit under those sections you contributed to, and I couldn't be more thankful.

I am going to hold off on the Harm Reduction section now - that is, including the (good) list of supplements you provided, because there's a specific direction with many facets I intent to take the HR portion of this - from injection techniques to quality of material to maintaining personal hygiene and taking "drug vacations" as well as supplements and NMDA-antagonists for tolerance prevention, but I'll keep your suggestions on tap.

Once again, a most heart-felt thanks from me to you.

~ vaya

simeons hcg diet protocol : no prob. thanks for letting me be a part of it

simeons hcg weight loss bottle pictures : vaya, is there anything else you're looking for? because i wouldn't mind doing more

simeons hcg weight loss protocol : Originally Posted by littlepenguin vaya, is there anything else you're looking for? because i wouldn't mind doing more Oh god, yes! LOL. We're still working on improving the very basics of the Wiki Project before undertaking anything more massive, and the Wiki above (not including your great contributions) probably took around seven or eight hours of research, verification, formatting, editing, etc.

Pretty much any section that has absolutely nothing under it I'd love to see filled first. Once all sections are tentatively completed, I plan on running through the finished product with a fine-toothed comb - kinda OCD about grammar, spelling, sentence structure and a professional presentation (which includes my going back through all 34, and likely many more, citations and transforming them into APA format - yech).

Basically the sections I'd like to see go up sooner rather than later are Trip Reports (these can be links to good, solid TRs posted here on Bluelight and, I suppose, others from Erowid or something, although I'll have to email Fire and see if I need permissions for that), Harm Reduction, Contraindications and Overdose, Methods of Use... I don't know if I really see a need for an external Links section given the volume of citations I've amassed but if anyone wants to compile a list of good scholarly articles (full-text, pdf or abstract) that'd be nice. I have a *ton* on my computer as it is, may as well put them to good use, huh?
Anything you think you'd want to tackle or are willing to research and learn about, I definitely encourage you to do so! Your help is invaluable; a Wiki, after all, is a community project!

Thanks again,
~ vaya

simeons method of weight loss : 2 questions:

'contraindications' - this basically means 'reasons not to use,' correct? would these be different than negative long/short term effects, or is it just listing the effects in deeper detail?

'methods of use' - is this the same thing as ROA? If so, you would like the roa's listed in detail?

simeons protocol for weight loss : Originally Posted by littlepenguin 2 questions:

'contraindications' - this basically means 'reasons not to use,' correct? would these be different than negative long/short term effects, or is it just listing the effects in deeper detail?

'methods of use' - is this the same thing as ROA? If so, you would like the roa's listed in detail? Yes, "methods of use" = ROA. If I were you, I would simply write something along these lines: Methamphetamine is most frequently insufflated, vaporized or intravenously. The hydrochloride salt of methamphetamine readily melts and vaporizes without smoking, making this ROA particularly efficient. The "rush" from IV'd methamphetamine is experientially more significant than IV amphetamine because the addition of a methyl group allows methamphetamine to readily cross the blood-brain barrier. Other route s of administration include buccal, oral, sublingual and rectal.
etc. etc.
(Sorry, I feel like I just wrote it for you, but add your own touches, expand on it if you wish to include bioavailabilties for the various ROA, and provide citations

Contraindications loosely refers to reasons not to use - for example, if one has a pre-existing heart condition, cardiovascular disease, a history of chemical dependency, use under the age of 12 amplifies the chances of adverse reactions, etc.
There are also substances, such as deprenyl, which can be very harmful when combined with methamphetamine. Things of that nature. "Contraindications" is distinctly different from a mere list of side effects that directly result from the drug in the bloodstream, yep!

Thank you once more!

~ vaya

simeons weight loss : I am in the midst of writing the contraindications, just fyi.

simeons weight loss cure : Bluelight's Methamphetamine Wiki Page

Hopefully it meets some expectations!

~ vaya

simeons weight loss cure protocol : i did a brief scan thru and it looks great!

simeons weight loss cure ptotcol : Appreciated animal_cookie thank you!!

simeons weight loss manuscript : contraindications

I. possible drug interactions:

- Sympathomimetics eg: MAOIs (isocarboxazid, linezolid, methylene blue, moclobemide,
phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine, chlorgyline, nialamide, pargyline,
befloxatone, brofaromine, moclobemide)
If taken within 2 weeks before, during, and after treatment with this medication,
in some cases a serious and possibly life threatening drug interaction may occur.
Very high blood pressure can occour. DO NOT COMBINE ANY MAOI WITH METHAMPHETAMINE!!

- Antidepressants (venlafaxine)
Can cause dangerous fluctuations in blood pressure and possible serotonin syndrome.

- Tricyclic antidepressants (amitriptyline, amoxapine, clomipramine, doxepin, imipramine, desipramine,
nortriptyline, protriptyline, trimipramine)
Taking methamphetime with tricyclics can change the way the brain reacts to methamphetamine,
possibly causing more side effects.

- SSRIs (fluoxetine, citalopram, fluvoxamine, paroxetine, sertraline)
Serotonin reuptake inhibitors may potentiate the pharmacologic response to sympathomimetic agents.

- NARIs/Noradrenaline Reuptake Inhibitors (mianserin)
Stimulant effects felt by methamphetamine are almost completely blocked by NARIs.

- Insulin
If taken with methamphetamine, insulin can increase your risk of low blood sugar
(hypoglycemia) because you may eat less while taking methamphetamine (it is an appetite
suppressant).

- Medications for high blood pressure (guanethidine)
Since psychotstimulants can increase blood pressure, they may counteract the effectiveness
of antihypertensives

- Beta blockers (atenolol)

- Medications that affect the acid level of the urine (sodium bicarbonate, acetazolamide)
Alkalinization of the urine can decrease the renal elimination of methamphetamines. Methamphetamine
effects may be prolonged, and the risk of toxicity may be increased.


- Other stimulant medications (e.g., methylphenidate, lisdexamfetamine)
Combining other stimulants with methamphetamine may decrease the effects of methamphetamine.

- Phenothiazines (chlorpromazine, thioridazine, fluphenazine, perphenazine, promethazine,
trifluoperazine)
If taken with methamphetamine, this may decrease the effectiveness of methamphetamine.

- Cough & Cold products (dextromethorpan)
Mixing cold medicines with methamphetamine may cause blood pressure to become
dangerously high or lead to irregular heart rythyms

- Isoniazid (INH)


- Ioflupane eg: dopamine transporter bin
Drugs that bind to the dopamine transporter with high affinity may interfere with the
image obtained using ioflupane I-123, which also binds to the dopamine transporter.

- SNRIs (venlafaxine)
Possibly causes seizures when combined with methamphetamine.


- Serotonergics (MDMA, St. Johns Wort, tramadol, pethidine, triptans)
These drugs have the potential to produce symptoms of serotonin toxicity

- Antipsychotics (colazapine)
These drugs antagonize the effects of dopamine at D2 receptor. Using methamphetamine
with any of these drugs can greatly reduce the efficacy of each drug. May also induce
a meth-related psychosis or psychotic symptoms, or antipsychotic-induced acute dystonias.


II. Pre-existing Conditions that should not be mixed with Methamphetamine

- Allergy to methamphetamine hydrochloride, Desoxyn, or any inactive component in the drug
- Heart conditions including heart disease, atherosclerosis, congestive heart failure, recent heart
attack, certain irregular heart rhythyms (arrhythmias)
- Have moderate to severe hypertension (high blood pressure)
- Severe agitation
- Overactive thyroid (hyperthyroidism)
- Glaucoma
- Have used a monoamine oxidase inhibitor (MAOI) within fourteen days
- Tourette's Syndrome (methamphetamine can exacerbate tics)
- Diabetes
- Pregnant or could be pregnant, or breastfeeding (methamphetamine is passed through breast milk and may effect an unborn baby resulting in low birth
weight)





I am so sorry it took me so long, I was having trouble "working" on my vacation Thanks for being patient with me. This is kind of a rough draft, there's more things I will be adding, but I just wanted to get this to you so you had something. Any questions or comments or things I can fix/improve, please let me know! Also, in the very very near future, I plan to attack the ROA section.

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