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enzyte vs extenze : I had some spare time, so I wrote this draft:


Mephedrone FAQ


1. What is Mephedrone?
Mephedrone, 4-Methylmethcathinone, is a potent CNS stimulant and empathogen. It is dopaminergic and most likely somewhat serotonergic. It is a white powder with a pungent odor that originated in Israel around 2007.

2. How is it taken?
Mephedrone is generally swallowed and/or insufflated.

3. What does it do?
It produces great CNS stimulation, dry mouth, increased perspiration, decreased appetite, very dilated pupils, occasional jaw tension and GI discomfort. It produces euphoric and empathetic feelings, both hardening and softening the ego, along with an impaired short term memory. It can also produces sores in the mouth and cause knees and elbows to turn slightly blue due to severe vasoconstriction. It is suspected to be both neuro and cardiotoxic.

4. How long does it last?
Mephedrone typically lasts 2-2.5 hours when taken orally, 1-2 hours when insufflated, 1 hour when IVed, and 1-2 hours when administered rectally.

5. How much is needed for a dose?
Orally: 200-300mg insufflated: 100-200mg IV: 75-100mg recatally: 75-100mg

6. Is it dangerous?
Yes, people have reported blue knees and elbows from vasoconstriction. It may be harmful to the brain and heart as well as irritating to mucous membranes when insufflated. Few people have died; however, some others have gotten severely ill after their first dose.

7. Is it addictive?
Mephedrone does not appear to cause physical dependence, though the compulsion to re-dose is intense. Few instances of psychological dependency have been noted; for the most part, once one has not had Mephedrone for 24-48 hours, the cravings severely diminish in presence. Despite this, many people have been addicted to mephedrone.

8. What is particularly harmful to mix with Mephedrone?
Stimulants are most dangerous, but not too much is known about combining Mephedrone with other drugs.

9. What are some beneficial supplements one can take to combat Mephedrone's detrimental health effects?
Tyrosine, Garlic and other vasodilators, Milk, and Fish Oils have been shown most effective thus far.

10. What happens during an overdose?
The user's heartrate will skyrocket and body temperature will increase. Certain places on extremities may turn blue and one may have difficulty breathing or moving.

enzyte vs viagra : Thoughts? Additional info?

enzyte zinc : "what is mephedrone?" - since FAQs are typically directed at people who dont know anything, perhaps relate the structure to methamphetamine, which basically everyone has heard of.
i havent handled the stuff personally, but all the other ketones i've handled had sweet smells, it seems unusual that mephedrone would smell pungent...

"What does it do?" - you should include what neurotransmitter systems it actually affects. i know its serotonergic based on the 4-methyl group, but aside from that, i'm not sure. i suspect its dopaminergic as well, and i cant remember well enough if norepi would also be affected

"What is particularly harmful to mix with Mephedrone?" - most certainly MAOIs and anything else that's dangerous to mix with serotonergics (such as other serotonergics). i seem to remember DXM being risky to mix with mdma, and this should correlate to other serotonergics. anything that, when mixed with mdxa leads to an increased risk of serotonin syndrome should probably be included here.


of course, i could be wrong about what NT systems it works on, since you cant accurately predict anything with structure alone...

eo brody green depression glass bowl : ^Perhaps pungent is the wrong word; I'm looking for something strong and gross . It's been compared to crab though.

eociniphilic gastritis : I had some spare time, so I wrote this draft:


Mephedrone FAQ


1. What is Mephedrone?
Mephedrone, 4-Methylmethcathinone, is a potent CNS stimulant and empathogen. It is dopaminergic and most likely somewhat serotonergic. It is a white powder with a pungent odor that originated in Israel around two years ago (2007). (more on chemistry- what is it similar to (methylone=bk MDMA for example)

2. How is it taken?
Mephedrone is generally swallowed and/or insufflated. It is occasionally (plugged) taken rectally or IVed.

3. What does it do?
It produces (great) strong CNS stimulation, dry mouth, increased perspiration, decreased appetite, very dilated pupils, occasional jaw tension and GI discomfort. It produces euphoric and empathetic feelings, (both hardening and softening the ego- too ambiguous), along with an impaired short term memory. It can also produce sores in the mouth and cause knees and elbows to turn slightly blue due to severe vasoconstriction. It is suspected to be both neuro and cardiotoxic. ie. toxic to brain cells and heart tissue

4. How long does it last?
Mephedrone typically lasts 2-2.5 hours when taken orally, 1-2 hours when insufflated, 1 hour when IVed, and 1-2 hours when administered rectally.

How long to come up on each method?

5. How much is needed for a dose?
Orally: 200-300mg insufflated: 100-200mg IV: 75-100mg recatally: 75-100mg

6. Is it dangerous?
Yes, people have reported blue knees and elbows [strike]from vasoconstriction[/strike[] from prolonged dosing (people have reported vasonconstriction at lower/first off doses). This suggests it is restricting the flow of blood to various body-parts (vasonconstriction), which could ultimately lead to permanent damage to veins and gangrene. The physiological basis for vasoconstriction is thought to be mephedrone's effect on serotonin receptors, some of which are involved in regulating blood flow. It may be harmful to the brain and heart as well as irritating to mucous membranes when insufflated. A Few people have died; however, some others have gotten severely ill after their first dose.

7. Is it addictive?
Mephedrone does not yet appear to cause physical dependence, though the compulsion to re-dose is intense for some. Mephedrone shares this characterstic with other dopaminergic stimulants, such as methamphetamine.
A Few instances of psychological dependency have been noted; however, for the most part, once one has not had Mephedrone for 24-48 hours, the cravings severely diminish in (presence) intensity
8. What is particularly harmful to mix with Mephedrone?
Stimulants are most dangerous, but not too much is known about combining Mephedrone with other drugs. The deaths attributed to mephedrone are largely thought to be due to combining it wth other stimulants.

9. What are some beneficial supplements one can take to combat Mephedrone's detrimental health effects?
Tyrosine, Garlic and other vasodilators (?), Milk, and Fish Oils have been shown most effective thus far. In effect, substances which gently increase blood circulation may be of benefit, but very little is known in the way of interactions, and some combinations as such, may be dangerous.

10. What happens during an overdose?
The user's heartrate will skyrocket and body temperature will increase. Certain places on extremities may turn blue and one may have difficulty breathing or moving. Death may also occurr.


Bobby, I added some stuff (in italics and put some brackets around weighted/biased comments (ie. the ego section, as well as 'great CNS stimulation'). There needs to be a more neutral tone.

You could also mention-

-Half life
-Metabolites
-Recovery techniques

Good FAQ, but it needs to be longer. I hope my additions made some sense

edit: Quoting it fucked up my italics.

eodd diet : New Mephedrone Addiction thread in EADD which may be worth a linky or looksee too. Seems to have given a few potential users a bit of food for thought.

eodd diet book : Originally Posted by Bob Loblaw ^Perhaps pungent is the wrong word; I'm looking for something strong and gross . It's been compared to crab though. For me, the smell of mephedrone always reminds me of powdered laundry detergent.

Definitely the smell, and clearly, psychologically, because of its fine white, powder form.

eodd diet comments from others : Good job on this one.............if this is the one going on wiki we should definitely include the mephedrone addiction thread link. I am one of those who feel that this one can be physically addicting. The symptoms are both mental and physical.

eodd diet help : Mephedrone is a manipulative little bastard.

eodd diet review : Originally Posted by Bob Loblaw It is a white powder with a pungent odor that originated in Israel aroubd two years ago (2007). I believe it originated long before then and there, though that may be where widespread recreational use began.

eodd diet reviews : I think MDPV is much better MEphedrone.

eodd every other day diet : We should add data on confirmed metabolites, their toxicity, and their relation to protracted, harmful vasoconstriction with prolonged use. Information on activity at various receptors and transporters will be speculative--the research has not yet been done.

ebola

eodd every other day diet scam : I think these dosage levels are to high, the first time I tried it I did 170 mg and didn't touch it for 6 months it scared me so much. I just recently tried it again and 20 mg snorted on (while on Xanax) and I felt like I was pushing it. Those of us sensitive to stimulants the stated doses are dangerous IMO.

eoe ada drug free : Originally Posted by theotherside26 Good job on this one.............if this is the one going on wiki we should definitely include the mephedrone addiction thread link. I am one of those who feel that this one can be physically addicting. The symptoms are both mental and physical. Very well may be one of the most addicting substances out there I'd say.

eoe esophagus : Hi,

If click HERE and scroll down, you'll see links to TEN Mephedrone megathreads (mainly thanks to us in the UK). Almost three years of discussion and more information than you could possibly imagine.

eoe m f v drug test : i miss the magic but dont get anywhere near the same effects as what i used to so i dont indulge anymore. i mean like barely noticeable euphoria or energy, and at bigger doses that those stated in the FAQ... and its not far off pure before people start saying that ha.

eola diet : I unapproved several more off-topic posts. Please remember that this thread is solely for material pertinent to revision of this FAQ.

ebola

eola diet drops : I think that in the OP the question 2. How is it taken? should be edited to include the routes of administration that are described in the questions 4 and 5.

plugging is not that rare a way to dose with mephedrone, when I was addicted to it I would regularly plug my doses.

eola weight loss : Originally Posted by Nexus298 I think these dosage levels are to high, the first time I tried it I did 170 mg and didn't touch it for 6 months it scared me so much. I just recently tried it again and 20 mg snorted on (while on Xanax) and I felt like I was pushing it. Those of us sensitive to stimulants the stated doses are dangerous IMO. I must agree, those doses should be reduced, unless you're recommending an average? Or a starter?

Might be a good idea to include legality, although this may not be the place for it.

eola weight loss drops : Couple of posts unapproved. This forum is for discussion of content for the BL Wiki, if you have particular questions about a drug please post in the relevant drug forum (try Basic Drug Discussion if you are unsure).

eom neuropathy : Originally Posted by ebola? We should add data on confirmed metabolites, their toxicity, and their relation to protracted, harmful vasoconstriction with prolonged use. Information on activity at various receptors and transporters will be speculative--the research has not yet been done.

ebola There is finally some science done on it! I think I posted this in ADD, but I'll give it here too.

Abstract

Background and purpose: The designer drug 1-(4-methylphenyl)-2-methylaminopropan-1- one (4-methylmethcathinone, mephedrone) is reported to possess psychostimulant, entactogenic and hallucinogenic effects. The purpose of this study was to examine the effects of acute administration of mephedrone on extracellular levels of dopamine (DA) and serotonin (5-HT) in the nucleus accumbens of awake rats and compare these effects to those induced by 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) and amphetamine.
Experimental approach: Microdialysis sampling was performed while simultaneously
recording locomotor activity in rats and the monoamines were determined by HPLC with electrochemical detection.
Key results: Mephedrone (3 mg.kg-1 s.c.) and (+)-amphetamine (1 mg.kg-1 s.c.) caused rapid increases in extracellular DA levels to 496% and 412%, respectively, whereas MDMA (3 mg.kg-1 s.c.) showed only a moderate effect (235. The corresponding 5-HT levels increased to 941% (mephedrone) and 911% (MDMA), but only to 165% following amphetamine. The calculated half-lives (t1/2) for elimination rate of mephedrone, MDMA and amphetamine-induced increases in extracellular DA levels were 25, 303 and 51 min, the corresponding t1/2 values for 5-HT were 26, 48 and 84 min, respectively.
Locomotor activation was highest for amphetamine, whereas both mephedrone and MDMA showed about three times lower and short-lasting effects.
Conclusions and implications: Mephedrone resembles the neurochemical and functional properties of MDMA, but also shows amphetamine-like effect on rapid release and elimination of DA in the brain reward system, a feature that may contribute to its potent reinforcing properties. J. Kehra,b*, F. Ichinoseb, S. Yoshitakeb, M. Goinya,b, T. Sievertssonb, F. Nybergc and T. Yoshitakea. Mephedrone, compared to MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and serotonin levels in nucleus accumbens of awake rats. British Journal of Pharmacology April 2011

And some analysis and what not....

So this shows that mephedrone produces peak levels in DA similar to amphetamine, and similar peak levels to MDMA in 5-HT. From another person:
More peak dopamine release than amphetamine, more serotonin release than MDMA, and a half-life of less than 30 minutes?! Well I think we can see why mephedrone was such a runaway success

eon clonzepam medications : Okay. I'm going to try to modify this, with my additions integrated.

Originally Posted by Bob Loblaw I had some spare time, so I wrote this draft:


Mephedrone FAQ


1. What is Mephedrone?
Mephedrone, 4-Methylmethcathinone, is a potent CNS stimulant and entactogen/empathogen. It's a potent releaser of dopamine, serotonin, and norepinephrine at typical doses. When reasonably pure, it appears as white powder or crystals, often with a pungent odor, as many ketones have. The compound originated in Israel around 2007.

2. How is it taken?
Mephedrone is generally swallowed and/or insufflated. A few people have taken the compound rectally, reporting good results. Fewer still have taken mephedrone intravenously, but this is NOT recommended: as a potent vasoconstrictor and pressor agent, the risks of cardiotoxicity varied types of inflammation and irritation near the injection site are high.

3. What does it do?
Mephedrone induces dramatic CNS stimulation, dry mouth, increased perspiration, decreased appetite, very dilated pupils, occasional jaw tension and GI discomfort. In terms of mental effects, mephedrone induces euphoric and empathetic feelings. While most report less empathy than with MDMA, such emotional opening is still distinct, but is also accompanied by cocaine like ego-inflation. Short-term memory impairment is to be expected.

Alarmingly, mephedrone induces sores in the mouth and can cause knees and elbows to turn slightly blue or red and blotchy due to severe vasoconstriction, but possibly through additional, undiscovered mechanisms. Alarmingly, these symptoms tend to get worse by far with repeated use, particularly with binging, and these symptoms can by far out-persist mephedrone's presence in the body. Neurologically, many report an MDMA-like hangover, again very severe with binges or addiction. Research very strongly suggests mephedrone's cardio-toxicity, but its neurotoxicity as well (see section on current research).

4. How long does it last?
Mephedrone typically lasts 2-2.5 hours when taken orally, 1-2 hours when insufflated, 1 hour when IVed, and 1-2 hours when administered rectally, though the highly euphoric peak is quite a bit briefer, compelling many users to dose with cocaine-type frequency. Mephedrone's first-order metabolite, 4-methyl-ephedrine, is metabolized far more slowly. Thus, many experience lengthy, dysphoric trailing stimulation.

5. How much is needed for a dose?
Orally: 150-250 mg insufflated: 75-150 mg IV: 50-100mg rectally: 50-100mg
(you likely do NOT want to take a potent vasoconstrictor rectally)

6. Is it dangerous?
Yes: people have reported blue knees and elbows from vasoconstriction, persisting heart palpitations, anxiety, and so on. Mephedrone is very likely harmful to the brain and heart as well as irritating to mucous membranes when insufflated. Few people have died; however, some others have gotten severely ill after their first dose.

7. Is it addictive?
Mephedrone, like other stimulants, does not appear to cause physical dependence, though the compulsion to re-dose is intense. With regular use, dependence similar to that seen with other stimulants occurs readily; however, for the most part, once one has not had Mephedrone for 24-48 hours, cravings severely diminish in presence.

8. What is particularly harmful to mix with Mephedrone?
Stimulants are most dangerous, but not too much is known about combining Mephedrone with other drugs. In general, drugs that prove unsafe in combination with MDMA will also prove unsafe with mephedrone, particularly MAO-inhibitors (the latter presenting the risk of serotonin syndrome).

ebola: can I get someone else's input here? I have little knowledge of what the sum of reported bioassays suggest.

9. What are some beneficial supplements one can take to combat Mephedrone's detrimental health effects?

Tyrosine, Garlic and other vasodilators, Milk, and Fish Oils have been shown most effective thus far.

10. What happens during an overdose?
The user's heartrate will skyrocket and body temperature will increase. Certain places on extremities may turn blue and one may have difficulty breathing or moving. 11. What are current research findings on mephedrone?

In "Beta-keto amphetamines: studies on the metabolism of the designer drug mephedrone and toxicological detection of mephedrone, butylone, and methylone in urine using gas chromatography–mass spectrometry", Meyer et al. confirmed that mephedrone metabolizes to 4-methyl-ephedrine, a highly cardiotoxic compound (2010, Analytical and Bioanalytical Chemistry, Volume 397, Number 3, 1225-1233, DOI: 10.1007/s00216-010-3636-5). 4-methyl-ephedrine is a potent adrenergic agent and vasoconstrictor, with a therapeutic index a couple to a few times more narrow than ephedrine's, and a duration outlasting mephedrone itself by a few times.

In "Mephedrone, compared to MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and serotonin levels in nucleus accumbens of awake rats", Kehr. et al. found mephedrone to be a potent releaser of all three monoamines, with a propensity for dopaminergic release in league with amphetamine, and a propensity to release serotonin in league with MDMA, suggesting a very high likelihood of neurotoxitiy (2011, British Journal of Pharmacology, DOI: 10.1111/j.1476-5381.2011.01499.x).

eon labs tizanidine : I hate mephedrone with a passion. Not only do I consider it a dodgy substance that someone decided to popularise to make money from the MDMA drought but I think it harmed the rave scene too.

eon medications : definitely an odd drug. only tried it twice and one of those times was some nasty stuff that was actually red and some berry flavored powder...it was nasty. the other time i tried it was some brand that sold a 1g capsule...i believe it was 1 g anyways...i took about half and felt ok but not much so i took the rest within an hr an was good for 5 or 6 hours it seems...this may not be completely accurate as it was a while back but it was a long time...i only tried it twice bc i didnt find out about the stuff til it was about to be banned...by the way...my capsule was lovey dovey brand

eonyx lithium ev batteries : Originally Posted by ebola? In "Beta-keto amphetamines: studies on the metabolism of the designer drug mephedrone and toxicological detection of mephedrone, butylone, and methylone in urine using gas chromatography–mass spectrometry", Meyer et al. confirmed that mephedrone metabolizes to 4-methyl-ephedrine, a highly cardiotoxic compound (2010, Analytical and Bioanalytical Chemistry, Volume 397, Number 3, 1225-1233, DOI: 10.1007/s00216-010-3636-5). 4-methyl-ephedrine is a potent adrenergic agent and vasoconstrictor, with a therapeutic index a couple to a few times more narrow than ephedrine's, and a duration outlasting mephedrone itself by a few times. so is vasoconstriction in itself damaging to the heart? if not, what causes the permanent damage to the heart that mephedrone and/or 4-methyl-ephedrine cause?

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