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day. Rebound anxiety is usually a result of abrupt discontinuation of this medication; patients who taper off are less likely to experience these symptoms.
Physical dependence is the major limiting factor against long-term use of alprazolam and other benzodiazepines.
Factors which determine the severity of the benzodiazepine withdrawal syndrome experienced during dose reduction of alprazolam include:
length of use
frequency of dosing
method of withdrawal
personality characteristics of the individual
previous use of cross dependent/cross tolerant drugs (alcohol or other sedative hypnotic drugs)
current use of cross dependent/cross tolerant drugs (alcohol or other sedative hypnotic drugs)
Use of short-acting high potency benzodiazepines for example alprazolam or lorazepam
Alprazolam has an exceptional history insofar soon after its introduction a large number of case reports were published in the medical literature of severe withdrawal symptoms related case reports of withdrawal psychoses, seizures and intense rebound anxiety upon discontinuation of alprazolam